• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    @ Composition pour l'enrobage d'une substance biologiquement active stable dans un milieu dont le pH est supérieur ou égal à 5 et qui permet la libération de la substance active dans un milieu dont le pH est inférieur ou égal à 3,5 constitué d'un liant à hydrophilie contrôlée non hydrosoluble, filmogène, éventuellement légèrement sensible aux variations du pH (zéine éventuellement associée à l'éthyl- cellulose) et d'une substance sensible aux variations du pH (charges minérales, polymères et copolymères basiques, chitosan), ainsi que les granulés constitués d'un noyau contenant la substance biologiquement active enrobé par cette composition.
    公开号:SU1540647A3
    申请号:SU853993196
    申请日:1985-12-19
    公开日:1990-01-30
    发明作者:Отан Пьер；Картилльер Андре；Пижон Раймон
    申请人:Otan Per；Kartiller Andre；Pizhon Rajmon；
    IPC主号:
    专利说明:

    This invention relates to agriculture.
    The purpose of the invention is to increase the stability of the composition at a pH of greater than or equal to 5 (P rumen) and the release of a biologically active substance at a pH of less than or equal to 3.5.
    When animals are fed medicinal drugs or biologically active substances (vitamins, amino acids), the rumen causes the enzymatic destruction of these substances and recordability from the time they are in the rumen (from several hours to several days)

    Cm
    and pH of the medium (from 5 to 6). For encapsulation of biologically active substances, a composition is proposed comprising a binder system of film-forming components and a substance sensitive to changes in pH,
    The compositions according to the invention can be obtained by dispersing or dissolving a very sensitive to changes in the pH of a substance, in some cases combined with an additive, in a solution or dispersion of a binding agent in an organic solvent or in a mixture of appropriately selected organic solvents in depending on the type of binder. Basically, the shell composition is obtained after evaporation of the solvent or solvents.
    The sheath compositions of the present invention are particularly useful when administering orally to ruminants. Coated substances are usually mixed with animal feed. Therapeutic or nutrients can be taerdom or liquid.
    The coated materials are granules in the form of microcapsules consisting of a central core surrounded by a continuous film of the composition of the shell. However, the active substances can also be dispersed in the composition of the shell. In general, the composition of the shell is 5-60% by weight of ganule or dispersion.
    Granules can be obtained by applying known techniques. Depending on the type of composition of the shell and, irrespective of the type of non-water soluble binder, either extrusion or spraying technology, or emulsions in the fluidized layer, or the technology of making capsules in a molten or semi-molten medium, or concentration type coatings are used. .
    The granules obtained according to the present invention are stable during storage and transport operations, are not destroyed in the manufacture of animal feed, and are not destroyed in animal feed reception.
    The size of the granules depends on the purpose of the particular animal species.

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    The active substances can be coated to obtain granules with a size of 0.1-5 mm. As active substances, granules contain methionine, lysine or vitamins (vitamin A), whose role is very important in fattening animals, especially ruminants.
    To determine the sensitivity of the shell compositions to pH changes, we used tests that measure salting out the active substance as a function of time at different pH values, in particular at pH 6 to pH 2, or at pH 5 to pI 1.5,
    The test consists of making the CLRNKI composition of the disk envelope, on the upper side of which a known amount of active substance is placed, and the other side of the disk comes into contact with the surface of the aqueous solution, which is magnetically stirred. The amount of exfoliated active substance in an aqueous solution is determined by sampling, the same sample being checked first at pH 6 and then at pH 2,
    Another test is to place between two identical disks of the shell composition of a known amount of active substance.
    This kit, which is sealed by bending the edges, is immersed in a certain amount of an aqueous solution stirred by a magnetic method. The amount of salted active substance is checked when sampling at pH 6, then at pH 2.
    The salting out of the active substance in the form of granules or microcapsules is investigated with stirring under certain conditions, namely, a known amount of granules or microcapsules in the medium is maintained at a constant pH and at 40 ° C. The salting out rates of the sample are compared at different pH values, in particular at pH 6 and 2.
    Example 1. According to the fluidized bed technology, a layer is coated with 200 g of methionine, previously granulated in the form of spherical particles. a titer of 98%, whose diameter is 0.5-0.6 mm, with a solution in tetrahydrofuran 60 g of an encapsulation composition consisting of 55% ethylcellulose, 30% dipropylene glycol
    and 25% copolymer of 2-vinylpyridine with styrene (70-30).
    Example 2. According to the fluidized bed technology, 200 g of methionine, previously granulated in the form of spherical particles with a titer of 98%, the diameter of which is 0.5-0.6 mm, are coated with a strain of tetrahydrofuran 60 g of the composition for a lyre capsule consisting of of 37.5% ethylcellulose, 37.5% dipropylene glycol and 25% copolymer 2-vinylpyridine with. styrene
    Example 3. According to the fluidized bed technology, 200 g of methionine, previously granulated in the form of spherical particles, with a diameter of 98%, whose diameter is 6 mm, is coated with a solution in tetrahydrofuran of 60 g of an encapsulation composition consisting of 40% ethyl cellulose, 40% propylene glycol and 20% copolymer of 2-vinylpyridine with styrene (70-30).
    Example 4. According to the fluidized bed technology, 200 g of methionine, previously granulated in the form of spherical particles with a titer of 93%, the diameter of which is 0.5-0.6 mm, is coated with a solution in tetrahydrofuran, 60 g of the encapsulation composition, from 45% ethylcellulose, 30% propylene glycol and 25% copolymer of 2-vinylpyridine with styrene (70-30).
    Example 5. According to the fluidized bed technology, 200 g of methionine, pre-granulated in the form of spherical particles with a titer of 98%, the average diameter of which is 0.5-0.6 mm, is coated with a solution in tetrahydrofuran of 60 g of an encapsulation composition consisting of 41.25% ethylcellulose, 33.75% propylene glycol and 25% copolymer of 2-methyl-5-vinylpyridine with styrene (80-20),
    Example 6. According to the fluidized bed technology, 200 g of methionine, previously granulated in the form of spherical particles with a titer; 98%, the average diameter of which is 095-0.6 mm, cover with a solution in tetrahydrofuran 60 g of an encapsulation composition consisting of 40% ethylene cellulose, 50% propylene glycol and 20% copolymer of 2-methyl-5-vinylpyridine with styrene ( 80-20).
    0
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    The result for examples 1-6 are presented in table. one,
    Example 7. According to the fluidized bed technology, 200 g of monochlorine lysine hydrate, previously granulated in the form of spherical particles, with a titer of 85%, the diameter of which is 1-1.25 mm, is coated with a solution and in tetrahydrofuran 200 g from 37.5% ethylcellulose, 37.5% propylene glycol and 25% copolymer of 2-vinylpyridine with styrene.
    At pH 2, the percentage of lysine monochlorohydrate that is released is .96%, after 30 minutes, and 100%, after 1 hour.
    At pH 6, the percentage of lysine monochlorohydrate released is 1%, after 3 ppm, 6% after bh and 65 after 24 h.
    Example 8. According to the fluidized bed technology with a bath equipped with a Wurster system, 350 g of methionine, previously granulated in the form of spherical particles with a titer of 98%, the average diameter of which is 0.5-0.63 mm, is coated with a solution ( 1000 cm of a mixture of 1,2-dichloroethane with ethanol, 1: 1 by volume), 20 g of an encapsulation composition formed of 85% ethylcellulose, 8.3% triacetin and 16.6% styrene copolymer with 2-vinylpyridine (29.6- 69.5 by weight) with specific viscosity 0S592, measured at a concentration of 5 g / l in dimethylformamide at 20 C.
    PRI me R 9. According to the technology of a fluidized bed with a bath equipped with a Wurster system, 250 g of methionine, previously granulated in the form of spherical parts. with a titer of 98%, the average diameter of which is 0.5-0.63 mm, is coated with a solution (dispersion in 1000 cm9 of a mixture of 1,2-dichloroethane with ethanol, 1: 1 by volume), 150 g of the encapsulation composition formed 60 % zein, 20% ethylcellulose, 6.6% triacetin, and 13.3 styrene copolymer with 2-vinylpyridine (29.5-69.5 by weight) with a specific viscosity of 0.592, measured at a concentration of 5 g / l in dimethylformamide at.
    Example 10. According to a fluidized bed technology with a bath equipped with a Wurster system, 350 g of methionine, previously granulated in the form of spherical particles, with a titer of 98%, the average diameter of which is 0.5-0.63 mm, is coated with a solution (dispersion of 1000 cm mixture of 1,2-dichloroethane with ethanol, 1: 1 by volume), 140 g of the composition for capsularity, formed of 57.1% zein, 14.3% ethylcellulose, 7.1% polyvinyl acetate, 7.1% triacetin and 20% copolymer of styrene with 2-vinylpyridine (29.5-69.5 by weight) with a specific viscosity of 0.592, measured at a concentration of 5 g / l in dimethylph rmamyde at 20 ° C,
    The results for examples 3-S are presented in Table. 2
    Example 11. According to a fluidized bed technology with a bath equipped with a Wurster system, 350 g of methionine, previously granulated in the form of spherical particles with a titer of 98%, the average diameter of which is 0.5-0.63 mm, is coated with a solution (dispersion see a mixture of 1,2-dichloroethane with ethanol, 1: 1 by volume), J20 g of an encapsulating composition composed of 50% zein, 25% ethylcellulose, 8.3% triacetone, and 16.6% copolymer of 2-vinvdgairidine with styrene (70-30), whose specific viscosity is 0.560, measured at a concentration of 5 g / p in dimethylformamide at 20 S.
    After 3 hours, evenly coated granules with a titer of 72.1% methionine are obtained,
    At pH 6, the release of methionine is 10%, after 6 hours, 25%, after 24 hours.
    At pH 2. The methionine release is 100%, after 15 minutes.
    Example 12. According to the fluidized bed technology in a bath equipped with a Wurster system, 350 g of lysine hydrochloride, pre-granulated in the form of spherical particles with a titer of 85%, with an average diameter of 0.63-0.8 mm, is coated with a solution (dispersion of 1000 see a mixture of 1,2-dichloroethane with ethanol, 1: 1 by volume), 120 g of the encapsulating composition, formed
    five
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    five
    0
    five
    0
    five
    0
    50% zein, 25% ethylcellulose, 8.3% triacetin and 16.6% copolymer of 2-vinylpyridine with styrene (70-30), the specific viscosity of which is 0.560, measured at a concentration of 5 g / l, in dimethylformamide at 20 ° C.
    Granules are obtained whose titer for lysine hydrochloride is 67.5%.
    Example 13: Operated as in Example 12, using the same encapsulation, to obtain g granules, the lysine chlorohydrate titer is 51.2%.
    权利要求:
    Claims (1)
    [1]
    The results for examples 12 and 13 are presented in table. 3. The invention formula
    A composition for encapsulating a biologically active substance, including a binder system of film-forming components and sensitive to changes in the pH of the substance, is about that, in order to increase the stability of the composition, at a pH above or equal to 5 rumen) and release of biologically active substance at pH less than or equal to 3.5; as film-forming substances of the binding system, the composition contains cellulose acetobutyrate and / or ethyl cellulose and / or pelevinilacetate, and / or zein, and additionally components that regulate hydrophilic acid. but the hydrophobic balance is selected from the group: propylene glycol, dipropylene glycol and triacetin, and the composition sensitive to changes in the pH of the substance contains styrene copolymers with 2-vinylpyridine or 2-methyl-5-vinylpyridine or chitosan in the following ratio of components,% : Film Forming Components
    binding system 37,5-80,0 Components that regulate
    hydrophilic hydrophobic balance 6.6-40.0 pH sensitive substance 9.0-25.0
    Table 1
    类似技术:
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    同族专利:
    公开号 | 公开日
    NZ214635A|1988-11-29|
    EP0188953A3|1986-08-13|
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    ES550212A0|1988-11-01|
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    DE3565450D1|1988-11-17|
    AU5146085A|1986-07-17|
    ES8900002A1|1988-11-01|
    AU594932B2|1990-03-22|
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    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    FR8419521A|FR2575040B1|1984-12-20|1984-12-20|NOVEL COMPOSITIONS FOR COATING FOOD ADDITIVES FOR RUMINANTS AND FOOD ADDITIVES THUS COATED|
    FR8419520A|FR2575039B1|1984-12-20|1984-12-20|COMPOSITIONS FOR COATING FOOD ADDITIVES FOR RUMINANTS AND FOOD ADDITIVES THEREFOR|
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